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Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptors

Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptors

  1. catseye
    M. Nakazi · U. Bauer · T. Nickel · M. Kathmann ·
    E. Schlicker

    Naunyn-Schmiedeberg’s Arch Pharmacol (2000)
    361:19–24

    ABSTRACT:

    We studied whether serotonin release in the
    CNS is inhibited via cannabinoid receptors. In mouse
    brain cortex slices preincubated with [3H]serotonin and superfused with medium containing indalpine and
    metitepine, tritium overflow was evoked either electrically (3 Hz) or by introduction of Ca2+ (1.3 mM) into Ca2+-free K+-rich (25 mM) medium containing tetrodotoxin. The effects of cannabinoid receptor ligands on the electrically evoked tritium overflow from mouse brain cortex slices preincubated with [3H]choline and on the binding of [3H]WIN 55,212–2 and [35S]GTPγS to mouse brain cortex membranes were examined as well.