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Interaction of Cimetidine with the Triazolobenzodiazepines Alprazolam and Triazolam

Interaction of Cimetidine with the Triazolobenzodiazepines Alprazolam and Triazolam

  1. Ilsa
    Abstract. The influence of cimetidine on the pharmacoki-netics of alprazolam and triazolam, two triazolobenzodiazepines metabolized by hepatic microsomal oxidation, was evaluated in a series of healthy volunteers. Subjects ingested single 1.0 mg dose of alprazolam or 0.5 mg doses of triazolamon two occasions, with and without concurrent administration of cimetidine (300rag) every 6h.