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Interethnic difference in omeprazole's inhibition of diazepam metabolism

Interethnic difference in omeprazole's inhibition of diazepam metabolism

  1. Bajeda
    Caraco Y, Tateishi T, & Wood AJ. (1995). Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clinical Pharmacology & Therapeutics, 58(1):62-72.


    Objectives: To compare the effect of omeprazole, a substrate and inhibitor of CYP2C19, on diazepam metabolism in white and Chinese subjects.

    Subjects and Methods: The study, which took place at a clinical research center in a University Hospital, was designed as a double blind, crossover, two-stage study; each stage lasted 21 days and was separated by 4 weeks. Subjects were eight white and seven Chinese men who were extensive metabolizers of debrisoquin and mephenytoin. The subjects received, in a randomized order, omeprazole, 40 mg/day, and placebo for 21 days, followed by a 10 mg oral dose of diazepam. Diazepam and desmethyldiazepam plasma concentrations were determined by HPLC during a 26-day period after diazepam administration.

    Conclusion: The extent of the inhibitory effect of omeprazole on diazepam metabolism is dependent on ethnicity. Further studies are needed to determine the mechanism responsible for this phenomenon.

    Discussion Thread