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Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline

Suggests that 5-HT2 receptors are involved

  1. Calliope
    European Journal of Pharmacology, 159 (1989) 41-46

    James B. Appel * and Patrick M. Callahan

    In order to further evaluate the extent to which particular 5-HT receptor subtypes (5-HT1 , 5-HT2 ) might be involved in the behavioral effects of hallucinogenic drugs, rats were trained to discriminate mescaline (10 mg/kg i.p.) from saline and were given substitution (generalization) and combination (antagonism) tests with putatively selective serotonergic and related neuroactive compounds. The mescaline cue generalized to relatively high doses of the 5-HT2 agonists, 2,5-dimethoxy-4-methylamphetarnine (DOM), LSD and psilocybin; the extent of generalization to 5-HT1 agonists (8-hydroxy-2-[diethylarnino]tetralin (8-0HDPAT), RU-24969 and 8-hydroxy-2-( di-n-propylamino]tetralin (TFMPP)) was unclear. Combinations of the training drug and sufficiently high doses of 5-HT2 antagonists (ketanserin, L Y-53857, pirenperone) were followed by saline-lever responding; less selective central 5-HT (metergoline), and DA (SCH-23390, haloperidol) antagonists, did not block the mescaline cue. These data suggest that 5-HT2 receptors are involved in the stimulus properties of mescaline.