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IRREVERSIBLE OPIATE AGONISTS AND ANTAGONISTS: THE 14-HYDROXYDIHYDROMORPHINONE AZINES

IRREVERSIBLE OPIATE AGONISTS AND ANTAGONISTS: THE 14-HYDROXYDIHYDROMORPHINONE AZINES

  1. H Bomber
    Further investigations into the molecular actions of the 14-hydroxydihydromorphinone hydrazones
    (naloxazone, oxymorphazone, and naltrexazone) have suggested that their irreversible actions
    can be explained by the formation of their azines. These azines, naloxonazine, naltrexonazine, and
    oxymorphonazine, irreversibly block opiate binding in vitro 20- to 40-fold more potently than their
    corresponding hydrazones, naloxazone, naltrexazone, and oxymorphazone. The blockade of binding
    by naloxonazine shows the same selectivity for high affinity, or ~1, sites as naloxazone.

Recent Reviews

  1. H Bomber
    H Bomber
    5/5,
    Version: 2009-06-11
    Wow, swiHB is both terrified and intrigued