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K-Opioids as Potential Treatments For Stimulant Dependance (Prisinzano et al, 2005)

K-Opioids as Potential Treatments For Stimulant Dependance (Prisinzano et al, 2005)

  1. Jatelka
    The AAPS Journal 2005; 7 (3) Article 61

    Thomas E. Prisinzano , Kevin Tidgewell, and Wayne W. Harding

    ABSTRACT
    Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the “dopamine hypothesis” has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor in mediating the abuse effects. Therefore, most treatments have focused on directly infl uencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of k opioid agonists. The k receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes of k opioid ligands that have been explored for this purpose.