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Long-Term Production of Ergot Peptides by Immobilized Claviceps purpurea in Semicontinuous and Conti

Long-Term Production of Ergot Peptides by Immobilized Claviceps purpurea in Semicontinuous and Conti

  1. ThirdEyeFloond
    Appl Environ Microbiol. 1993 July; 59(7): 2029–2033.
    Wilfried Dierkes, Michael Lohmeyer, and Hans-Jürgen Rehm

    Abstract
    The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl2 (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.