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Lorazepam Substitutes for the Alcohol Stimulus in Social Drinkers (2003)

Lorazepam Substitutes for the Alcohol Stimulus in Social Drinkers (2003)

  1. Jatelka
    Psychopharmacology (Berl). 2003 Mar;166(2):181-7.

    Jackson A (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Stephens DN (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Duka T (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1).

    RATIONALE: The alcohol discriminative stimulus has been extensively studied in animals and demonstrated to be pharmacologically complex. In contrast, however, the alcohol stimulus has been less frequently studied in humans. OBJECTIVES: The aim of the experiments reported here was to characterise pharmacologically an alcohol discriminative stimulus in social drinkers. METHODS: Volunteers were first trained to discriminate a dose of 0.2 g/kg alcohol from placebo, using an established method. We then investigated the generalisation response and subjective effects following a range of doses of the gamma-amino-butyric acid (GABA)(A) benzodiazepine-receptor agonist lorazepam (0, 0.5, 1 and 2 mg, PO). RESULTS: Low doses of lorazepam (0.5 and 1 mg) did not cross-generalise with the alcohol stimulus and produced only minimal subjective effects. However, a dose of 2 mg lorazepam substituted (60.8%) for the stimulus ( P