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Maturation-related changes in tolerance development to hexobarbital after short term treatment with

Maturation-related changes in tolerance development to hexobarbital after short term treatment with

  1. ThirdEyeFloond
    Brain Res. 1993 Jan 15;600(2):345-8.


    Korkmaz S, Carlsson S, Wahlström G.


    Male rats at six different ages received diazepam on a 4-day treatment schedule. Cross-tolerance to hexobarbital was tested several times during withdrawal period with an anaesthesia threshold technique. Pattern of cross-tolerance was different at different ages. Thus, age and maturation of the rat is a variable which must be considered in studies of tolerance to diazepam.
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