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MDMA (‘‘Ecstasy’’) and Its Association with Cerebrovascular Accidents

MDMA (‘‘Ecstasy’’) and Its Association with Cerebrovascular Accidents

  1. DmTryp
    RESULTS: An analysis of variance revealed that mean cortical [123I]R91150 binding ratios were significantly lower in recent MDMA users than in former MDMA users and control subjects. This finding suggests down-regulation of 5-HT2 receptors caused by MDMA-induced 5-HT release. Furthermore, in MDMA users, low cortical 5-HT2 receptor densities were significantly associated with low cerebral blood vessel volumes (implicating vasoconstriction) and high cortical 5-HT2
    receptor densities with high cerebral blood vessel volumes (implicating vasodilatation) in specific brain regions.
    CONCLUSION: These findings suggest a relationship between the serotonergic system and an altered regulation of 5-HT2 receptors in human MDMA users. MDMA users may therefore be at risk for cerebrovascular accidents resulting from alterations in the 5-HT neurotransmission system.