1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

MDMA reinstates cocaine-seeking behaviour in mice

MDMA reinstates cocaine-seeking behaviour in mice

  1. Synesthesiac
    Eur Neuropsychopharmacol. (javascript:AL_get(this, 'jour', 'Eur Neuropsychopharmacol.');) 2009 Jun;19(6):391-7

    Trigo JM (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Orejarena MJ (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Maldonado R (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Robledo P (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract).

    Background: MDMA effects are mediated by monoaminergic systems, which seem to play a
    central role in cocaine craving and relapse.

    Methods: CD1mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug selfadministration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.

    Results: Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine selfadministration and contingent cues were previously extinguished.

    Conclusions: Acute MDMA can reinstate cocaine-seeking behaviour in mice.