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MDMA reinstates cocaine-seeking behaviour in mice

MDMA reinstates cocaine-seeking behaviour in mice

  1. Synesthesiac
    Eur Neuropsychopharmacol. (javascript:AL_get(this, 'jour', 'Eur Neuropsychopharmacol.');) 2009 Jun;19(6):391-7

    Trigo JM (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Orejarena MJ (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Maldonado R (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Robledo P (http://www.drugs-forum.com/pubmed?t....Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract).

    Background: MDMA effects are mediated by monoaminergic systems, which seem to play a
    central role in cocaine craving and relapse.

    Methods: CD1mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug selfadministration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.

    Results: Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine selfadministration and contingent cues were previously extinguished.

    Conclusions: Acute MDMA can reinstate cocaine-seeking behaviour in mice.