1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Mechanism for the interaction between triazolam and cimetidine

Mechanism for the interaction between triazolam and cimetidine

  1. Gradient
    ABSTRACT
    Four normal volunteers each received three intraduodenal infusions of 0·5 mg triazolam solutions. Three treatments were:
    1 a pH 2·3 solution in which 47 per cent of the dose had hydrolysed to form a triazolo-benzophenone (TB);
    2 a pH 6·0 solution containing negligible TB;
    3 the pH 6·0 solution administered during cimetidine treatment (1200mg day-1)
    TB was stable in serum and only very low TB serum concentrations were observed from the pH 2·3 treatment. No difference was observed in any triazolam pharmacokinetic parameter between the pH 6·0 and the pH 2·3 treatments. Cimetidine increased the triazolam AUC and Cmax by 54 and 35 per cent, respectively. These results indicate that TB undergoes extensive presystemic conversion to triazolam and the triazolam-cimetidine interaction occurs primarily through a reduction in triazolam clearance.