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Mephedrone, an Abused Psychoactive Component of “Bath Salts” and Methamphetamine Congener, Does

Mephedrone, an Abused Psychoactive Component of “Bath Salts” and Methamphetamine Congener, Does

  1. catseye
    Journal of Neurochemistry
    Mariana Angoa-Pérez, Michael J. Kane, Dina M. Francescutti, Katherine E. Sykes, Mrudang M. Shah, Abiy M. Mohammed, David M. Thomas, Donald M. Kuhn
    22 Dec 2011

    ABSTRACT:
    Mephedrone (4-methylmethcathinone) is a β-ketoamphetamine with close structural analogy to
    substituted amphetamines and cathinone derivatives. Abuse of mephedrone has increased
    dramatically in recent years and has become a significant public health problem in the US and
    Europe. Unfortunately, very little information is available on the pharmacological and
    neurochemical actions of mephedrone. In light of the proven abuse potential of mephedrone and
    considering its similarity to methamphetamine and methcathinone, it is particularly important to
    know if mephedrone shares with these agents an ability to cause damage to dopamine nerve
    endings of the striatum.