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Metabolism of cathinone to (–)-norephedrine and (–)-norpseudoephedrine (1986)

Metabolism of cathinone to (–)-norephedrine and (–)-norpseudoephedrine (1986)

  1. Anonymous
    Brenneisen R, Geisshusler S, Schorno X. 1986..
    Journal of Pharmacy and Pharmacology 38:298–300.

    S-(-)-Cathinone (S-(-)-alpha-aminopropiophenone) is the major active principle of khat leaves (Catha edulis), which are widely used in East Africa and the Arab peninsula as an amphetamine-like stimulant. After oral administration of synthesized cathinone (isomers, racemate), 22-52% was recovered in 24 h urine samples mainly as aminoalcohol metabolites. With GC/MS, HPLC and CD, the main metabolite of S-(-)-cathinone was identified as R/S-(-)-norephedrine and the main metabolite of R-(+)-cathinone as R/R-(-)-norpseudoephedrine. Both aminoalcohols are formed by a stereospecific keto reduction.