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Metabolism of Designer Drugs of Abuse (RF Staack & HH Maurer 2005)

Metabolism of Designer Drugs of Abuse (RF Staack & HH Maurer 2005)

  1. ThirdEyeFloond
    Current Drug Metabolism, 2005, 6, 259-274

    Authors: Roland F. Staack and Hans H. Maurer

    "This paper reviews the metabolism of new designer drugs of abuse that have
    emerged on the black market during the last years. Para-methoxyamphetamine (PMA), para-methoxymethamphetamine (PMMA) and 4-methylthioamphetamine (4-MTA), were taken into consideration as new "classical" amphetamine-derived designer drugs. Furthermore, N-benzylpiperazine (BZP), 1-(3,4-methylenedioxybenzyl)piperazine (MDBP), 1-(3-
    trifluoromethylphenyl)piperazine (TFMPP), 1-(3-chlorophenyl)piperazine (mCPP) and 1-(4-methoxyphenyl)piperazine (MeOPP) were taken into consideration as derivatives of the class of piperazine-derived designer drugs, as well as a-pyrrolidinopropiophenone (PPP), 4’-methoxy-a-pyrrolidinopropiophenone (MOPPP), 3’,4’-methylenedioxy-a-pyrrolidinopropiophenone (MDPPP), 4’-methyl-a-pyrrolidinopropiophenone (MPPP), and 4’-methyl-a-pyrrolidinoexanophenone (MPHP) as derivatives of the class of a-pyrrolidinophenone-derived designer drugs. Papers describing identification of in vivo or in vitro human or animal metabolites and cytochrome P450 isoenzyme dependent metabolism have been considered and summarized."