- Study Author(s):
- Rae R. Matsumoto,* , Michael J. Seminerio , Ryan C. Turner, Matthew J. Robson, Linda Nguyen, Diane B. Miller, and James P. O’Callaghan
- Journal Name:
- Pharmacology & Therapeutics, Vol 144, Issue 1, pp 28-40
- Publication Date:
- October 2014
Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.
Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.
A summary of available information relating to methamphetamine toxicity and hyperthermia