From the abstract:
- Study Author(s):
- Yun-Hsiang Chen, Kuang-Lun Wu, and Chia-Hsiang Chen
- Journal Name:
- PLoS One. 2012; 7(11): e48335.
- Publication Date:
- November 6, 2012
“Herein, we investigated the effects of meth on influenza A virus replication in human lung epithelial A549 cells. The cells were exposed to meth and infected with human influenza A/WSN/33 (H1N1) virus. The viral progenies were titrated by plaque assays, and the expression of viral proteins and cellular proteins involved in interferon responses was examined by Western blotting and immunofluorescence staining. We report the first evidence that meth significantly reduces, rather than increases, virus propagation and the susceptibility to influenza infection in the human lung epithelial cell line, consistent with a decrease in viral protein synthesis.”