1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Mu Opioid Receptor Regulation And Opiate Responsiveness (2005).

Mu Opioid Receptor Regulation And Opiate Responsiveness (2005).

  1. ex-junkie
    Raehal, K. M., & Bohn, L. M. (2005). Mu Opioid Receptor Regulation And Opiate Responsiveness. The AAPS Journal 2005, 7(3), Article 60. Available from http://www.aapsj.org.


    ABSTRACT

    Opiate drugs such as morphine are well known for their
    ability to produce potent analgesia as well as such unwanted side effects as tolerance, physical dependence, respiratory suppression and constipation. Opiates act at opioid receptors, which belong to the family of G protein-coupled receptors. The mechanisms governing mu opioid receptor (m OR) regulation are of particular interest since morphine and other clinically important analgesics produce their pharmacological effects through this receptor. Here we review recent advances in understanding how opioid receptor regulation can impart differential agonist efficacy produced in vivo.