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Neurochemistry Underlying Relapse to Opiate Seeking Behaviour (2009)

Neurochemistry Underlying Relapse to Opiate Seeking Behaviour (2009)

  1. ex-junkie
    Brown, R. M., & Lawrence, A. J. (2009).
    Neurochemistry Underlying Relapse to Opiate Seeking Behaviour. Neurochem Res, 34,1876–1887
    doi: 10.1007/s11064-009-9967-y.


    Abstract

    Relapse is a major clinical problem and
    remains a major challenge in the treatment of addictions. A goal of current research is to gain a greater understanding of the neurochemistry underlying relapse to opiate use. Factors which trigger relapse in humans such as stress, exposure to opiates and/or drug-associated cues, can also trigger opiate-seeking in animals. This review will overview preclinical studies relating to the neurochemistry of opiate-seeking with a focus on studies published from 2005 to present.