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Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations

Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations

  1. Crazy Insane Sanity
    Based upon animal experiments and early clinical trials neurokinin-1receptor antagonists showed neurokinin-1receptor antagonists showed promise as novel antidepressants. promise as novel antidepressants.
    Subsequently, however, more extensive Subsequently, however, more extensive clinical trials did not reveal evidence of clinical trials did not reveal evidence of efficacy in depression.The development of efficacyin depression.The development of novel antidepressants will require a better novel antidepressants will require a better understanding of the neural basis of understanding of the neural basis of antidepressant action in humans.