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Nicotine Modulates Evoked GABAergic Transmission in the Brain

Nicotine Modulates Evoked GABAergic Transmission in the Brain

  1. Mindless
    The significance of nicotinic enhancement of evoked GABAergic transmission in the brain is potentially far-reaching, because GABA is the principal inhibitory neurotransmitter in the brain. It remains to be seen whether the effects we observe here are representative of the relationship between nAChRs and GABAergic transmission in other regions of the brain.

    In summary, nicotine increased spontaneous GABAergic synaptic currents recorded from chick SPL neurons in a dosedependent manner. At low concentrations (50–100 nM), nicotine enhanced evoked GABAergic transmission, whereas higher concentrations of nicotine reduced the evoked GABAergic current. Moreover, the nicotinic effect on GABAergic transmission appears to be through a presynaptic mechanism.