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Opioids, Reward and Addiction: An Encounter of Biology, Psychology and Medicine (Van Ree et al, 1999

Opioids, Reward and Addiction: An Encounter of Biology, Psychology and Medicine (Van Ree et al, 1999

  1. Jatelka
    Pharmacological reviews 1999, Vol.51(2), pp.341-96

    Van Ree, J M ; Gerrits, M A ; Vanderschuren, L J

    From the present review, it can be concluded that endogenous opioids probably play a role in the vulnera-bility to become dependent, the daily dynamics of drug-taking, and the relapse. However, different endogenous opioids systems may be involved, present in the VTA and the limbic system, respectively. It seems that the encounter among biology, psychology, and medicine was fruitful and that stimulation of multidisciplinary re-search can contribute to further understanding of the intriguing phenomenon of addiction. Macht (1915) con-cluded his review in the beginning of this century with, “If we trace the history of opium from its earliest begin-nings to the brilliant researches of recent years, if we but compare the analytic and synthetic, chemical, physio-logic and pharmacological studies of the same old drug with the fantastic and puerile effusions on the subject of our medical predecessors, we cannot help being im-pressed with the long strides forward which medicine has made; yet, on the other hand, our very recent studies on opium and its alkaloids serve but to emphasize the more our meager knowledge of the subject and the still greater task before us”.