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Opioids, sleep architecture and sleep-disordered breathing

Opioids, sleep architecture and sleep-disordered breathing

  1. Spucky
    Summary Opioid use whether acute or chronic, illicit or therapeutic is prevalent
    in Western societies. Opioid receptors are located in the same nuclei that are active
    in sleep regulation and opioid peptides are suggested to be involved in the induction
    and maintenance of the sleep state. m-Opioids are the most commonly used opioids
    and are recognized respiratory depressants that cause abnormal awake ventilatory
    responses to hypercapnia and hypoxia. Abnormal sleep architecture has been
    reported during the process of opioids induction, maintenance and withdrawal.
    During induction and maintenance of opioid use there is reduction of rapid eye
    movement (REM) sleep and slow wave sleep. More recently, central sleep apnoea
    (CSA) has been reported with chronic opioid use and 30% of stable methadone
    maintenance treatment patients have CSA. Given these facts, it is sobering to note
    the paucity of human data available regarding the effects of short and long-term
    opioid use on sleep architecture and respiration during sleep. In this manuscript, we
    review the current knowledge regarding the effects of m-opioids on sleep and
    respiration during sleep and suggest research pathways to advance our knowledge
    and to explore the possible responsible mechanisms related to these effects.

Recent Reviews

  1. h2uk
    Version: 2010-03-12
    Very Interesting article, explains a lot about why chronic heroin users & MMT patients can experience insomnia, disturbed sleep, breathing irregularities as well as stress and anxiety etc.

    Good upload Spucky