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Pentobarbital for Severe Gamma-Butyrolactone Withdrawal

Pentobarbital for Severe Gamma-Butyrolactone Withdrawal

  1. catseye
    Marco L.A. Sivilotti, MD, MSc, Michael J. Burns, MD, Cynthia K. Aaron, MD, Michael J. Greenberg, MD

    ANNALS OF EMERGENCY MEDICINE, 38:6, DECEMBER 2001


    TOXICOLOGY/ORIGINAL CONTRIBUTION


    Study objective:
    Gamma-hydroxybutyrate (GHB) and gamma-
    butyrolactone (GBL) have become popular drugs of abuse. Acute overdose with either agent results in a well-recognized syndrome of central nervous system and respiratory depression.
    Recently, a withdrawal syndrome has been described for GHB. We report a severe form of GBL withdrawal, characterized by delirium, psychosis, autonomic instability, and resistance to benzodiazepine therapy.