1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions

Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions

  1. Gradient
    M Kacevska, M Ivanov, M Ingelman-Sundberg
    Clinical Pharmacology & Therapeutics (2011) 89 6, 902–907.


    Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. It can be anticipated that interindividual epigenetic differences that affect the expression of drug-metabolizing and disposition enzymes as well as of epigenetic effectors, such as pharmaceutical compounds, will have significant roles in determining an individual's susceptibility to ADRs. In this brief review, we provide an epigenetics perspective on ADRs.

    Discussion Thread