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Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.) (2004)

Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.) (2004)

  1. Bajeda
    J Ethnopharmacol. 2004 Aug;93(2-3):153-60

    Anke J (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Ramzan I (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)

    Kava kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum Forst. f.), was used for many centuries as a traditional beverage in the Pacific Islands. During the past few decades, kava has also gained popularity in Western countries as well, due to its anxiolytic and sedative properties. However, in recent years, kava has been implicated in several liver failure cases which led to its ban in many countries and this has prompted wide discussion on its relative benefits and risks as a social beverage and a herbal remedy.