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Pharmacokinetics and Pharmacodynamics of Multiple Sublingual Buprenorphine Tablets in Dose-Escalatio

Pharmacokinetics and Pharmacodynamics of Multiple Sublingual Buprenorphine Tablets in Dose-Escalatio

  1. H Bomber
    In this investigation, the pharmacokinetic and pharmacodynamic properties were determined of multiple doses of sublingual tablets containing either buprenorphine alone or buprenorphine
    and naloxone. Subjectswere experienced opiate
    users who received escalating doses (4-24 mg) of buprenorphine either alone or in combination with naloxone. Peak concentration (Cmax) and area under the concentration-time curves (AUCs) increased for both buprenorphine and naloxone
    with escalating doses. Significant differences were
    found across the range of doses administered for doseadjusted Cmax for both tablet formulations and for the doseadjusted AUCs for the buprenorphine-naloxone tablets.

Recent Reviews

  1. H Bomber
    H Bomber
    5/5,
    Version: 2009-06-11
    This data was surprisingly hard to track down