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Pharmacokinetics and Side-Effects of Clonazepam and Its 7- Amino-Metabolite in Man

Pharmacokinetics and Side-Effects of Clonazepam and Its 7- Amino-Metabolite in Man

  1. H Bomber
    Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated
    in a prospective study of 27 newly diagnosed epileptics and correlated with specified
    side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/
    ml, and individual values ranged from 30 to about 8Ong/ml. There was a linear correlation between
    changes in dose and the resulting plasma levels, which indicates first order elimination kinetics.
    Side-effects were frequent, but neither their severity nor their occurrence could be related to plasma levels or to the rate of increase in plasma concentration of the drug.
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