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Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing (

Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing (

  1. Jatelka
    British Journal of Pharmacology 1999 Sep;48(3):317-22

    Ammon S, Hofmann U, Griese EU, Gugeler N, Mikus G.

    AIMS: The pharmacokinetics of dihydrocodeine (DHC) and its active metabolite dihydromorphine (DHM) were assessed after a single oral dose of DHC and after increasing doses of DHC at steady-state.

    Methods Twelve healthy male volunteers (18-45 years, CYP2D6 extensive metabolizers (EMs), MR