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Pharmapena Psychonautics: Human Intranasal Sublingual and Oral Pharmacology of 5-Methoxy-N,N-Dimethy

Pharmapena Psychonautics: Human Intranasal Sublingual and Oral Pharmacology of 5-Methoxy-N,N-Dimethy

  1. Jatelka
    The Journal of Psychoactive Drugs 2001 Oct-Dec;33(4):403-7

    Ott J

    Summarized are psychonautic bioassays (human self-experiments) of pharmepéna--crystalline 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; O-Me-bufotenine), at times combined with crystalline beta-carbolines (harmaline or harmine). These substances were administered via intranasal, sublingual and oral routes, by way of pharmacological modeling of diverse South American shamanic inebriants (principally the snuffs epéna/nyakwana, prepared from barks of diverse species of Virola.) Intranasal, sublingual and oral psychoactivity of 5-MeO-DMT, and the 1967 Holmstedt-Lindgren hypothesis of the paricá-effect--intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAOI) beta-carbolines from stems of Banisteriopsis caapi admixed with the snuffs--have been confirmed by some 17 psychonautic bioassays. Salient phytochemical and psychonautic literature is reviewed.