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Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating α2-Ad

Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating α2-Ad

  1. Seaquake
    Nicholas A. Flavahan

    Phenylpropanolamine (dl-norephedrine) was one of the most widely used therapeutic agents to act on the sympathetic nervous system. Because of concerns regarding incidents of stroke, its use as a nasal decongestant was discontinued. Although considered an α1-adrenergic agonist, the vascular adrenergic pharmacology of phenylpropanolamine was not fully characterized. Unlike most other circulations, the vasculature of the nasal mucosa is highly enriched with constrictor α2-adrenoceptors.