1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Polymorphism in ‘L’ shaped lipids: structure of N-, O-diacylethanolamines with mixed acyl chains

Polymorphism in ‘L’ shaped lipids: structure of N-, O-diacylethanolamines with mixed acyl chains

  1. Anonymous
    Chemistry and Physics of Lipids 162 (2009) 25–33
    Pradip K. Tarafdar, Musti J. Swamy

    Although solid state polymorphism in lipids has been established by spectroscopic and calorimetric
    studies long ago, only in a few cases crystal structures of different polymorphs of the same compound
    have been reported, possibly due to difficulties in obtaining high quality single crystals of individual
    polymorphs. Recent studies show that N-, O-diacylethanolamines (DAEs) can be derived by the Oacylation
    of the stress-related lipids, the N-acylethanolamines under physiological conditions. In this
    study, two DAEs with mixed acyl chains, namely N-palmitoyl, O-octanoylethanolamine and N-palmitoyl,
    O-decanoylethanolamine have been synthesized and their three-dimensional structures were determined.
    Both the compounds were found to adopt ‘L’ shaped structures and exist in two polymorphic
    forms,  and . In the  form a mixed-type chain packing has been observed whereas in the  form
    the chain packing is symmetric. Similar polymorphic forms are likely to exist in other ‘L’ shaped lipids
    such as 1,3-diacylglycerols and ceramides, where polymorphism has been detected earlier, but threedimensional
    structures – which can give precise information about the packing at atomic resolution –
    have not been reported.