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Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin ne

Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin ne

  1. Anonymous
    Lancet. 1998 Oct 31;352(9138):1433-7.
    McCann UD, Szabo Z, Scheffel U, Dannals RF, Ricaurte GA.

    Summary
    Background (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a popular recreational drug that
    selectively damages brain serotonin (5-HT) neurons in animals at doses that closely approach those used by humans. We investigated the status of brain 5-HT neurons in MDMA users.

    Methods
    We enrolled 14 previous users of MDMA who
    were currently abstaining from use and 15 controls who had never used MDMA. We used positron emission tomography (PET) with the radioligand carbon-11-labelled McN-5652, which selectively labels the 5-HT transporter. We analysed whether there were differences in 5-HT transporter binding between abstinent MDMA users and participants in the control group. Blood and urine samples were taken and tested to check for abstinence.

    Findings
    MDMA users showed decreased global and
    regional brain 5-HT transporter binding compared with controls. Decreases in 5-HT transporter binding positively correlated with the extent of previous MDMA use.

    Interpretation
    Quantitative PET studies with a ligand
    selective for 5-HT transporters can be used to assess the status of 5-HT neurons in the living human brain. We show direct evidence of a decrease in a structural component of brain 5-HT neurons in human MDMA users.