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Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors

Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors

  1. ThirdEyeFloond
    The Cannabinoid Receptors p329-360

    Jenny L. Wiley and Billy R. Martin

    Abstract
    Most psychoactive substances produce a broad array of in vitro and in vivo pharmacological effects in the central nervous system (CNS). Marijuana and its primary psychoactive substituent, Δ9-tetrahydrocannabinol (Δ9-THC), are no exceptions. Although many of these effects are mediated through the actions of cannabinoids on central cannabinoid CB1 receptors, the bioassay systems that have been used to assess these in vivo and in vitro effects of cannabinoids have varying degrees of pharmacological specificity. The purpose of this chapter is to describe and to evaluate the bioassays most commonly used to detect and characterize cannabinoid pharmacology. Although cannabinoids have been tested in many in vivo and in vitro procedures other than those described here, the focus of this review is on the bioassays that specifically target cannabinoids (particularly their abuse-related properties). The first half of the chapter will focus on in vivo models in which cannabinoids are active while the last half will concentrate on in vitro models.
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