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Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation

Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation

  1. Bajeda
    Psychopharmacology (Berl). 1995 Oct;121(4):470-5.

    Pearl SM (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Johnson DW (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Glick SD (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).

    Study sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. The results, showing that morphine pre-exposure affects ibogaine activity, suggest that variable histories of opioid exposure might account for individual differences in the efficacy of ibogaine to inhibit opioid addiction.