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Psychophysiological Responses to Drug-Associated Stimuli in Chronic Heavy Cannabis Use

Psychophysiological Responses to Drug-Associated Stimuli in Chronic Heavy Cannabis Use

  1. Bajeda
    Wolfling, Klaus, Herta, Flor, & Grusser, S.M. (2008). European Journal of Neuroscience, 27, 976-983.

    Due to learning processes originally neutral stimuli become drug-associated and can activate an implicit drug memory, which leads to a conditioned arousing 'drug-seeking' state. This condition is accompanied by specific psychophysiological responses. The goal of the present study was the analysis of changes in cortical and peripheral reactivity to cannabis as well as alcohol-associated pictures compared with emotionally significant drug-unrelated and neutral pictures in long-term heavy cannabis users. The potency of visual drug-associated cues to capture attention and to activated drug-specific memory traces and accompanying physiological symptoms embedded in a cycle of abstinence and relapse - even in a 'so-called' soft drug - was assessed for the first time.

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