- Study Author(s):
- Yi-Chih Chen, Chih-Ken Chen, and Liang-Jen Wang
- Journal Name:
- BMC Psyciatry
- Publication Date:
Background: Comorbid anxiety symptoms,in patients with a primary anxiety disorder or a mood disorder, leads to
poor patient outcomes and burdens the healthcare system. This pilot study evaluated the feasibility of
extended-release quetiapine fumarate (quetiapine XR) for the treatment of patients with either a primary anxiety
disorder or a mood disorder with comorbid anxiety symptoms compared to a placebo, as an adjunct to
Methods: Thirty-nine patients with a diagnosis of a primary anxiety disorder or a mood disorder with comorbid
anxiety symptoms were enrolled in this study. Patients with a stable dose of antidepressant therapy were
randomized according to a 2:1 probability of receiving either quetiapine XR or a placebo adjunctive treatment for
8 weeks. The efficacy was assessed by the Hamilton Anxiety Rating Scale (HAM-A) and the Clinical Global
Impression of severity (CGI-S) score at baseline, week 1, 4, and 8.
Results: A total of 35 patients were included in this intention-to treat (ITT) population for the efficacy analysis
(quetiapine XR: 22 patients; placebo: 13 patients). At week 4, statistically significant differences were observed on
both the HAM-A score (p = 0.003) and the CGI-S score (p = 0.025), favouring the quetiapine XR (−13.00 ± 4.14)
compared to placebo (−6.63 ± 5.42). However, no statistically significant difference was observed between the two
groups with regard to changes from the baseline to week 8 on the HAM-A score (p = 0.332) or the CGI-S score
(p = 0.833).
Conclusions: Augmentation of antidepressant treatment with quetiapine XR did not result in clinical improvement
according to the outcome measure of anxiety using the HAM-A and CGI-S scores at week 8, among the patients
with either a primary anxiety disorder or a mood disorder with comorbid anxiety symptoms. However, treatment
with quetiapine XR as an adjunct to antidepressant therapy appeared to provide a short-term benefit at 4 weeks.
Further study is needed with a larger sample size, randomized controlled design and control of the
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Quetiapine fumarate augmentation for patients with a primary anxiety disorder or a mood disorder: a
Efficacy of quetiapine in treatment of anxiety disorders