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Residual effects of flurazepam and brotizolam on psychomotor performance (1983)

Residual effects of flurazepam and brotizolam on psychomotor performance (1983)

  1. Jatelka
    British Journal f Pharmacology 1983;16 Suppl 2:347S-351S

    Krueger H, Müller-Limmroth W

    Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time and reading errors were not impaired with brotizolam. There were residual effects with 30 mg flurazepam. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time, and reading errors were impaired compared with placebo and 0.25 mg brotizolam. Subjective assessments of performance correlated with measured performance. There was a decrease with flurazepam (visuo-motor coordination and visuo-mental processing time) compared with placebo.