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Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of 5-H

Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of 5-H

  1. syntelman
    3,4-Methylenedioxymethamphetamine (MDMA) causes persistent decreases in brain 5-HT content and 5-HT transporter (SERT) binding, with no detectable changes in SERT protein. Such data suggest that MDMA impairs 5-HT transmission but
    leaves 5-HT nerve terminals intact. To further test this hypothesis, we carried out two types of experiments in rats exposed to high-dose MDMA. First, we examined the effects of MDMA on SERT binding and function using different in
    vitro assay conditions. Next, we treated rats with the 5-HT precursor, l-5-hydroxytryptophan (5-HTP), in an attempt to restore MDMA-induced depletions of 5-HT.
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