1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats

Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats

  1. NeuroChi
    Rhodiola rosea L. is one of the most popular adaptogen and anti-stress
    plants in European and Asiatic traditional medicine. Its pharmacological
    properties appear to depend on its ability to modulate the activation of
    several components of the complex stress-response system. Exposure to
    both physical and psychological stress reduces feeding in rodents. The
    aim of this work was thus to determine whether in rats an hydroalcoholic
    R. rosea extract standardized in 3% rosavin and 1% salidroside (RHO)
    reverses hypophagia induced by (1) physical stress due to 60min
    immobilization; (2) intracerebroventricular injection of corticotrophinreleasing
    factor (CRF, 0.2g/rat), the major mediator of stress responses
    in mammals; (3) intraperitoneal injection of Escherichia coli
    lipopolysaccharide (LPS, 100g/kg); (4) intraperitoneal administration
    of fluoxetine (FLU, 8 mg/kg). The effect of the same doses of the plant
    extract was also tested in freely-feeding and in 20 h food-deprived rats.
    RHO was administered acutely by gavage to male Wistar rats 1h before
    the experiments. The results show that at 15 and 20 mg/kg, RHO reversed
    the anorectic effects induced both by immobilization and by
    intracerebroventricular CRF injection. Moreover, at the same doses, RHO
    failed to reduce the anorectic effect induced both by LPS and FLU, and
    did not modify food intake in both freely-feeding and food-deprived rats.
    These findings strongly demonstrated that RHO is able selectively to
    attenuate stress-induced anorexia, providing functional evidence of
    claimed adaptogen and anti-stress properties of Rhodiola rosea L.