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Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

  1. catseye
    Onder Albayram, Judith Alferink, Julika Pitsch, Anastasia Piyanova, Kim Neitzert, Karola Poppensieker,
    Daniela Mauer, Kerstin Michel, Anne Legler, Albert Becker, Krisztina Monory, Beat Lutz, Andreas Zimmer, and Andras Bilkei-Gorzo

    PNAS July 5, 2011 vol. 108, no. 27

    Abstract:
    Brain aging is associated with cognitive decline that is accompanied by progressive neuroinflammatory changes. The endocannabinoid system (ECS) is involved in the regulation of glial activity and influences the progression of age-related learning and
    memory deficits. Mice lacking the Cnr1 gene (Cnr1−/−), which encodes the cannabinoid receptor 1 (CB1), showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of
    principal neurons in the hippocampus.