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Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: A

Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: A

  1. Behrang
    Journal of Alzheimer's Disease, Vol. Preprint, No. Preprint, Pages 1-5, 2016

    Assaf Shelef, Yorama Barak, Urib Berger, Dianna Paleacu, Shellya Tadger, Igora Plopsky, Yehuda Baruch

    Abstract:
    -Background: Tetrahydrocannabinol (THC) is a potential treatment for Alzheimer’s disease (AD).
    -Objective: To measure efficacy and safety of medical cannabis oil (MCO) containing THC as an add-on to pharmacotherapy, in relieving behavioral and psychological symptoms of dementia (BPSD).
    -Methods: Eleven AD patients were recruited to an open label, 4 weeks, prospective trial.
    -Results: Ten patients completed the trial. Significant reduction in CGI severity score (6.5 to 5.7; p < 0.01) and NPI score were recorded (44.4 to 12.8; p < 0.01). NPI domains of significant decrease were: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress.
    -Conclusion: Adding MCO to AD patients’ pharmacotherapy is safe and a promising treatment option.

    Keywords:
    Alzheimer’s disease, behavioral and psychological symptoms of dementia, cannabis, tetrahydrocannabinol

    http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150915
    http://www.ncbi.nlm.nih.gov/pubmed/26757043
    DOI: 10.3233/JAD-150915