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Serotonin Neurotoxicity in Rats After Combined Treatment With a Dopaminergic Agent Followed by a Non

Serotonin Neurotoxicity in Rats After Combined Treatment With a Dopaminergic Agent Followed by a Non

  1. NeuroChi
    JOHNSON, M. P., X. HUANG AND D. E. NICHOLS.

    There is increasing evidence linking dopamine (DA) to the long-term serotonergic (5-HT) neurotoxic
    effects of certain substituted amphetamines such as 3,4-methylenedioxymethamphetarnine (MDMA).

    The present study was
    undertaken to examine the importance of DA metabolism, uptake inhibition and release in the long-term effects of these drugs by
    combining various dopaminergic agents with an analogue of MDMA that had low neurotoxic liability, namely 5,6-methylenedioxy-
    2-aminoindan (MDAI).

    This study compares different short and long term effects of MDMA and MDAI.

    Discussion Thread