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Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses

Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses

  1. testodan
    Minimum therapeutic doses of paroxetine and citalopram produce 80% occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used
    [11C]DASB positron emission tomography to measure occupancies of three other selective serotonin reuptake inhibitors (SSRIs) at minimum therapeutic doses.
    The relationship between dose and occupancy
    was also investigated.