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Serum Vasoconstrictor (Serotonin)- III. Chemical Inactivation

Serum Vasoconstrictor (Serotonin)- III. Chemical Inactivation

  1. Synchronium
    In order to determine which reagents were most suitable for abolishing the vasoconstrictor activity of serum, the inactivation of a beef serum vasoconstrictor (serotonin) concentrat,e by chemical reagents was studied. Certain oxidizing and halogenating agents, especially potassium persulfate, potassium permanganate, and iodine, were found to be effective at high dilution. By comparing the quantity of iodine required for inactivation of the concentrate and pure serotonin, evidence was obtained favoring the view that serotonin is solely responsible for the vasoconstrictor activity of serum.