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Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects

Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects

  1. H Bomber
    The pharmacokinetics and pharmacodynamics of the benzodiazepine anxiolytic alprazolam (1 mg orally) were compared between young and elderly healthy volunteers. Eight young subjects (mean age 29.8 years) and eight elderly volunteers (mean age 68.4 years) received oral placebo and alprazolam (1.0 mg) in a randomized, double-blind, singledose crossover study. In the elderly subjects, plasma concentrations were higher, although
    not significantly so, than in young volunteers 0.25, 0.5, and 0.75 hours after dosage. Apparent elimination half-life, time of maximum concentration, maximum concentration, volume of distribution, and apparent clearance were similar for the two groups.
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