1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Spice drugs as a new trend: Mode of action, identification and legislation

Spice drugs as a new trend: Mode of action, identification and legislation

  1. catseye
    Toxicology Letters, 197(3), pp157–162
    June,2010
    I. Vardakou, C. Pistos, Ch. Spiliopoulou

    ABSTRACT:
    The present review highlights the existing monitoring and legislation status of synthetic cannabinoids in
    Spice” products and alert research community about the identification and risk assessment problems of
    these compounds. Available data were collected by various literature search engines. All valuable information about psychoactive properties, safety profile, clinical data and detection problems for synthetic cannabinoids and their use as “herbal highs” were managed to spot and summarise. “Spice” contains synthetic cannabinoids that bind to cannabinnoid-like receptors and they are stronger than natural cannabis. Chronic abuse of “Spice” has linked with signs of addiction syndrome and withdrawal symptoms similar to syndromes observed in cannabis abuse. These cannabinoids can be considered as new products to be added to the list of “designerdrugs”.Although it remains unclear where and how the actual production of the herbal mixtures takes place, it is evident that producers are purposely risk the health of consumers to skim high profits. Only recently a number of countries in Europe, as well as in US and Canada banned
    the use of these substances. The difficulty in identification of related compounds leads to the necessity for the availability of reference standards in order to aid toxicological analyses.