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Stimulus Effects of N-Monoethyl-1- (3,4-Methylenedioxyphenyl)- 2- Aminopropane (MDE) and N-Hydroxy-

Stimulus Effects of N-Monoethyl-1- (3,4-Methylenedioxyphenyl)- 2- Aminopropane (MDE) and N-Hydroxy-

  1. Anonymous
    Pharmacology Biochemistry & Behavior, Vol. 22, pp. 723-729, 1985
    Glennon et al

    Eighteen rats were trained to discriminate 1.0 mg/kg of (+)-amphetamine sulfate from saline in a two-lever operant procedure. Once responding was stable, these animals were administered various doses of sixteen different methoxy-substituted phenylisopropylamines in tests of stimulus generalization. Of three possible mono-methoxyphenyfisopropylamines, all three produced amphetamine-appropriate responding, but none was as potent as racemic amphetamine. The amphetamine-stimulus did not completely generalize to any of the di- or trimethoxyphenylisopropylamines.