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Structure–Activity Relationships of Classical Cannabinoids

Structure–Activity Relationships of Classical Cannabinoids

  1. ThirdEyeFloond
    The Cannabinoid Receptors p3-19

    Raj K. Razdan
    Abstract
    In this chapter an overview of the more recent developments in the structure–activity relationships (SARs) of classical cannabinoids is discussed, especially the profound pharmacological effects produced by various chemical entities in the side chain at C-3, the hydroxyl at C-1, C-11, and hydroxyalkyl chains at C-6. Also cardiovascular studies point to the presence of a novel cannabinoid subtype receptor and the antagonist activity of cannabidiol has opened up new areas for research. Ligands, which had either a unique pharmacological profile, were potent agonists, partial agonists/antagonists, or were CB2 selective, were identified, generating leads with the potential to be drugs in the treatment of various diseases.