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Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chroma

Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chroma

  1. ThirdEyeFloond
    Legal Medicine
    Volume 11, Supplement 1, April 2009, Pages S429-S430

    Miroslava Rohanova and Marie Balikova

    Abstract

    para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC–MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication.
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